twiist-patient

https://s31352.pcdn.co/wp-content/uploads/twiist-patient-header-1-scaled.png

Take Control of Diabetes—Your Way, Every Day

A smarter insulin delivery experience designed to adjust with your life, deliver precise dosing,
and help you stay in range with greater confidence.

Adaptability

Your routine isn’t fixed—and your insulin delivery shouldn’t be either. Adjust for meals, activity, or schedule changes as they happen. Personalized targets and flexible settings help your therapy fit into your lifestyle.

Certainty

Know your insulin is being delivered as intended. Integrated monitoring confirms dosing accuracy and can alert you early if something isn’t right—so you can act quickly.

Effectiveness

Smart automation continuously adapts based on your glucose data, helping to anticipate changes and adjust insulin delivery in real time—supporting more stable outcomes.

Get Started

Complete the form to see if you qualify and get personalized guidance on starting with twiist.


 

INDICATIONS FOR USE
The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription.
The twiist Loop algorithm is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, control the delivery of correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater. The twiist Loop algorithm is intended for single-patient use and requires a prescription.
The twiist Automated Insulin Delivery System includes a simple bolus calculator available when Loop is off. It is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator entered blood glucose, insulin sensitivity, insulin to carbohydrate ratio, target glucose values, and current insulin on board.

CONTRAINDICATIONS

The twiist AID System is not intended for anyone unable or unwilling to:

  • Test blood glucose (BG) levels as recommended by their healthcare provider
  • Maintain sufficient diabetes self-care skills.
  • See their healthcare provider regularly
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

 

The user must not:

  • Have difficulty seeing
  • Have difficulty hearing
  • Have deficient cognitive capabilities
  • Have physical impairments that would make operating the pump or iPhone difficult

Product not yet available outside of the U.S.

REFERENCES
  1. Sequel Med Tech – twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide.
  2. Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: Sequel Med Tech – twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide; lnsulet – Omnipod 5 Automated Insulin Delivery System User Guide; Medtronic – MiniMed 780G system User Guide; Beta Bionics – iLet Bionic Pancreas System User Guide. The following reported 2 U/hr basal rate: Tandem Diabetes Care – t:slim X2 Insulin Pump User Guide; Tandem Diabetes Care – Tandem Mobi System User Guide.
  3. lnsulet – Omnipod 5 Automated Insulin Delivery System User Guide.
  4. Medtronic – MiniMed 780G system User Guide.
  5. Beta Bionics – iLet Bionic Pancreas System User Guide.
  6. Tandem Diabetes Care – t:slim X2 Insulin Pump User Guide.
  7. Tandem Diabetes Care – Tandem Mobi System User Guide.
  8. Lum JW, et al. A Real-World Prospective Study of the Safety and Effectiveness of the Loop Open Source Automated Insulin Delivery System. Diabetes Technol Ther. 2021;23(5):367-375.
  9. Klonoff DC, et al. Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion. J Diabetes Sci Technol. 2024;18(6):1472-1479.
  10. Wong JJ, et al. Psychosocial Effects of the Loop Open-Source Automated Insulin Delivery System. J Diabetes Sci Technol. 2023;17(6):1440-1447.
  11. Butterfield RD, et al. Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump With Acoustic Volume and Flow Sensing in Simulated High-Consequence Situations. IEEE Open J Eng Med Biol. 2024;5:593-599.
*The twiist™ Savings Program is available to individuals with a valid prescription and commercial insurance that covers twiist. Eligible participants can receive a Starter Kit for $0 and pay no more than $50 for Refill Kits. This offer is not valid for individuals enrolled in Medicare, Medicaid, or any other federal or state programs, or for cash-paying patients and non-covered claims. It is available only in the U.S. and is not valid in Puerto Rico, U.S. Territories, or where prohibited by law. While most commercially insured participants qualify for the $50 Refill Kit offer, those with high-deductible plans who haven’t met their deductible may pay more than $50 per Refill Kit until their deductible is met. The maximum benefit is $200 per Refill Kit for covered claims. Terms are subject to change. Call us at 1-877-489-4478 or contact your insurance provider to confirm coverage.
†Sequel is working on adhesive options for on-body wear. Alternative adhesive options are available through third-party providers.
‡Results obtained with the Loop algorithm using a non-twiist device.